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Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility. Genetic correlations were estimated using the same LD score regression settings as for heritability calculations. Bouras , C. Help Learn to edit Community portal Recent changes Upload file. Christopher R. The IVW method confers the greatest statistical power for estimating causal associations 59 , but assumes that all variants are valid instruments and can produce biased estimates if the average pleiotropic effect differs from zero.

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